What happens during brachytherapy?

radiotherapy tolerance tests

SHORT VERSION

Before brachytherapy initiation, the dose, radioactive source (radioactive substance), and number of sessions will be determined by the radiation oncologist. Depending on the radioactive source to be implanted, medical imaging may be required, such as computerized tomography (CT), magnetic resonance imaging (MRI), or ultrasonography, to determine the treatment plan and/or to guide the source implantation. The first step is to place the support. This device, also called the vector, contains the radioactive sources. General or locoregional anesthesia may be necessary, like for any other surgical procedure, to implant the material safely and without pain. Then, the treatment course (treatment duration and number of sessions) will depend on the used technique and on the dose rate (high-dose rate, low-dose rate, low pulsed-dose rate). For example, in pulsed-dose rate brachytherapy, the source is implanted in contact with the tumor area for 2 to 5 days during which radiation-emitting pulses alternate with rest phases. This requires hospitalization in an isolated room with lead walls. In high-dose rate brachytherapy, a support with high dose radioactivity is placed in the body for a very short time (few minutes), and does not require hospitalization. These sessions may be repeated once or twice per week.

Before brachytherapy initiation, the dose, radioactive source (radioactive substance), and number of sessions will be determined by the radiation oncologist. Depending on the radioactive source to be implanted, medical imaging may be required, such as computerized tomography (CT), magnetic resonance imaging (MRI), or ultrasonography, to determine the treatment plan and/or to guide the source implantation.

The first step is to place the support. This device, also called the vector, contains the radioactive sources. General or locoregional anesthesia may be necessary, like for any other surgical procedure, to implant the material safely and without pain.

Then, the treatment course (treatment duration and number of sessions) will depend on the used technique and on the dose rate (high-dose rate, low-dose rate, low pulsed-dose rate). For example, in pulsed-dose rate brachytherapy, the source is implanted in contact with the tumor area for 2 to 5 days during which radiation-emitting pulses alternate with rest phases. This requires hospitalization in an isolated room with lead walls. In high-dose rate brachytherapy, a support with high dose radioactivity is placed in the body for a very short time (few minutes), and does not require hospitalization. These sessions may be repeated once or twice per week.

brachytherapy traitement

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FIRST TESTS TO PREDICT A PATIENT’S RADIOSENSITIVITY

NovaGray develops and commercializes the first radiotherapy tolerance tests for patients treated for breast or prostate cancer.

Performed before the start of radiotherapy with a simple blood draw, the tests assess the patients’ individual radiosensitivity and determine their risk of developing late complications after radiotherapy.

WHY DO A RADIOSENSITIVITY TEST?

Knowing a patient’s individual radiosensitivity is important information that can help:

  • Reassure the patient in preparation for radiotherapy
  • Guide physicians in choosing the most appropriate treatment plan
  • Adapt patient follow-up after radiotherapy

Team NovaGray

NovaGray develops radiotherapy tolerance tests for breast and prostate cancer patients. NovaGray's mission is to help personalize cancer treatment by assessing each patient's individual sensitivity before starting radiotherapy. NovaGray technology has been validated by multi-center prospective clinical trials. NovaGray tests are recommended by the French Society of Radiation Oncology (SFRO).